Tert polymorphisms

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August undefined, 2024

Web27 Aug 2024 · Background. Studies have identified that the telomerase reverse transcriptase (TERT) gene polymorphism rs10069690 (C>T) is associated with cancer risk, but the results remain inconclusive.Methods. To provide a more precise estimation of the relationship, we performed a meta-analysis of 45 published studies including 329,035 cases and 730,940 … Web5 May 2024 · In BC, mutation of the TERT promoter is rare; therefore, other genetic changes have been described such as gene amplification and the presence of gene copy number gains or single nucleotide polymorphisms (SNPs), which may play a regulatory function in TERT expression and be associated with different telomere lengths [13,14,15].

Associations of TERT polymorphisms with hepatocellular carcinoma risk …

Web14 Jan 2014 · Background: Enzymatic activity of Telomerase Reverse Transcriptase (TERT) is important in maintaining the telomere length and has been implicated in cancer and aging related pathology. Since cancer susceptibility as well as longevity of dogs vary between breeds, this study involved sequencing the entire TERT gene of Canis familiaris from DNA … WebIt is a complex system composed of telomerase reverse transcriptase (TERT), telomerase RNA component and telomerase-associated protein 1 (TEP1).TERTis an important factor in maintaining telomere DNA length and chromosome stability.TERTis silently expressed in normal somatic and non-proliferative cells. ... (TNKS) gene polymorphism and telomere ... def of pharisee

(PDF) TERT Genotype Polymorphism: A Glance of Change …

Web11 Jun 2024 · Recently, polymorphisms in the TERT gene promoter were demonstrated to increase TERT transcription activity. 17, 18 Given the crucial role of TERT in the activation of telomerase, polymorphisms in the TERT gene might be associated with cancers via their effects on the expression of TERT. Web19 Nov 2024 · The TERT gene is situated at chromosome 5p15.33 in humans, and is an integral and essential part of the telomerase holoenzyme.TERT gene is 42 kb long and consists of 15 introns and 16 exons with a 260 bp promoter core ().The reverse transcriptase domain is encoded by 5–9 exons. The TERT transcript can be spliced into … Web13 Jun 2024 · The TERT rs2736100 polymorphism increases cancer risk: A meta-analysis Abnormal telomerase activity is implicated in cancer initiation and development. The … feminist dystopia handmaid\u0027s tale

Human TERT promoter polymorphism rs2853669 is associated …

Increased risk of developing lung cancer in Asian patients carrying …

Web13 Mar 2024 · TERT, a catalytic subunit of the enzyme telomerase, is critical for telomerase activity and has great importance in cancer progression. The activation of telomerase, … WebPolymorphisms near the telomerase reverse transcriptase ( TERC) gene have been associated with telomere length. What are the new findings? The major allele at polymorphism rs10936599 is associated with an increased risk of colorectal carcinomas and adenomas, but is also associated with longer telomeres. def of phantomWebThree genetic variants in TERT were considered polymorphisms because they were observed in normal donors and were not associated with telomere shortening; they … feminist duties and obligations to society

"WebHuman telomerase reverse transcriptase ( TERT ) is essential for the maintenance of telomere DNA length, chromosomal stability and cellular immortality. We hypothesized that TERT polymorphisms are associated with risk of … " - Tert polymorphisms

Tert polymorphisms

Relationship between Telomere Length, TERT Genetic Variability and TERT …

Web23 Jul 2015 · Telomerase reverse transcriptase (TERT) maintains telomere ends during DNA replication by catalyzing the addition of short telomere repeats. The expression of telomerase is normally repressed in somatic cells leading to a gradual shortening of telomeres and cellular senescence with aging. Web1 Jul 2024 · Associations of TERT polymorphisms with hepatocellular carcinoma risk in a Han Chinese population Associations of TERT polymorphisms with hepatocellular carcinoma risk in a Han Chinese population Int J Clin Exp Pathol. 2024 Jul 1;10 (7):7776-7783. eCollection 2024. Authors

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Web1 Feb 2024 · Polymorphism of the TERT gene determines the different disease development and pathological manifestations of BPH in the Chinese Han population the Northwest … Web1 Apr 2016 · Our data suggest that TERT rs2736100 polymorphisms are associated with an increased risk of glioma, which is similar to the result reported by Zhou et al. [25]. …

Web15 Nov 2015 · Previous studies suggested that the telomerase reverse transcriptase (TERT) gene polymorphism is associated with demographic and clinical features strongly …

Web25 Oct 2024 · We aimed to investigate associations between mucin 5B (MUC5B) and telomerase reverse transcriptase (TERT) polymorphisms and telomere length (TL) with … WebThe present meta-analysis, comprising 3,354 cases and 3,518 controls, explored the association between TERT rs2736098 polymorphisms and LC risk. It was observed that the TERT rs2736098 polymorphism was significantly correlated with increased risk of LC. In the stratified analysis by countries, control groups, and genotype test methods, similar ...

WebTelomerase reverse transcriptase (TERT) activity is up-regulated in several types of tumors including glioblastoma (GBM). In the present study, 128 primary glioblastoma patients were examined for single nucleotide polymorphisms of TERT in blood and in 92 cases for TERT promoter mutations in tumors.

Web31 Dec 2024 · We investigated the possible influence of TERC and TERT genetic variation and leukocyte telomere length (LTL) on human lifespan. Four polymorphisms of TERT and three polymorphisms of TERC were examined in a sample of elderly subjects (70–100 years). After nine years of follow-up, mortality data were collected, and sub-samples of … def of pharmacologicalWeb30 Jun 2015 · Telomerase reverse transcriptase (TERT) activity is up-regulated in several types of tumors including glioblastoma (GBM). In the present study, 128 primary glioblastoma patients were examined for single nucleotide polymorphisms of TERT in blood and in 92 cases for TERT promoter mutations in tumors. TERT promoter mutations were … def of pharaohWeb6 Jan 2024 · In this study, we selected single nucleotide polymorphisms (SNPs) from three different LTL related genes (TERC (telomerase RNA component), TERT (telomerase reverse transcriptase) and RTEL1 ... def of pharmaceuticalWebWe hypothesized that TERT polymorphisms are associated with risk of childhood acute lymphoblastic leukemia (ALL). We first conducted a case-control study of 570 ALL cases … feminist economics historyWebHuman telomerase reverse transcriptase ( TERT ) is essential for the maintenance of telomere DNA length, chromosomal stability and cellular immortality. We hypothesized … feminist economics jcrWeb11 Apr 2024 · TERT, located in the human 5p15.33 locus, encodes a catalytic subunit of telomerase and exerts a pivotal role in the maintenance of telomere DNA length and … def of pharmingWeb8 Mar 2024 · TERT as the catalysis subunit of telomerase can regulate the level of mitochondrial reactive oxygen (32, 33). The telomere length or telomerase gene TERC and TERT polymorphisms were correlated with age, the morbidity of tumors and chronic cardiovascular diseases (34–42). These past studies were mostly regarding in chronic … def of pharyngitis